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Orlistat Powder 96829-58-2

Orlistat Powder 96829-58-2

Raw Orlistat Powder 96829-58-2 Skype: fwk2014 Whatsapp: +86 15871358773 Email: lling@51chemall.com

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 Orlistat Powder 96829-58-2 Basic Information

Product Name: Orlistat;Xenical;Alli;Iraplax
CASNO.: 96829-58-2
Appearance: White or white crystalline powder
Molecular Formula: C29H53NO5
Molecular Weight: 495.735
Melt Point: <50ºC
Stocking Term: Refrigerator
Minimum Order Quantity:10 Gram
Payment Term: TT/Westunion/Moneygram
Delivery Time: Shipping time usually within 24 hours after confirming payment if no accidents

Orlistat is a saturated derivative of lipstatin, an effective natural pancreatic lipase inhibitor isolated from the bacteria Streptomyces toxytricini, which acts mainly on the gastrointestinal tract and inhibits the digestion of fat in the gastrointestinal tract. Enzymes, including pancreatic esters and gastric esters, reduce the absorption of fat by gastrointestinal esters to aid weight loss, but still need to be combined with exercise and diet, and have the effect of losing weight.

The effectiveness of orlistat in promoting weight loss is well founded. Data from clinical trials showed that people who received orlistat were reduced by about 2-3 kilograms compared to those who did not take the drug within a year. In addition, orlistat can also lower blood pressure moderately. Even studies have pointed out that it can prevent the onset of type 2 diabetes, either from weight loss itself or other effects. In a large trial, orlistat was found to reduce the risk of 40% of diabetes in obese people who have been shown to have abnormal glucose metabolism.

 Orlistat Powder 96829-58-2 Usage

Orlistat is a drug used to treat obesity. In a one-year clinical trial, between 35.5% and 54.8% of subjects reduced their weight by more than 5%, although the reduced weight was not all fat. Subjects between 16.4% and 24.8% reduced their weight by more than 10%. After stopping the use of orlistat, a large number of subjects recovered their weight and recovered about 35% of their weight. In obese people with type 2 diabetes, after taking orlistat for four years, the population had 6.2% of the total obese population, which was lower than the placebo-treated group (9.0%). A significant drop in blood pressure can also be seen in patients who have been taking orlistat for a long time (average systolic blood pressure decreased by 2.5 mmHg and diastolic blood pressure decreased by an average of 1.9 mmHg).

 Orlistat Powder 96829-58-2 Taboo

Absorptive patients

Allergic to orlistat

Insufficient gallbladder function (eg, patients undergoing cholecystectomy)

Pregnant or breastfeeding women

Use caution when you have the following conditions: biliary stricture, impaired liver function, pancreatic disease

 Orlistat Powder 96829-58-2 Side Effects

Gastrointestinal problems are the main side effects of this drug, including steatorrhea (thin, oily stools due to large amounts of unabsorbed fat reaching the large intestine), fecal incontinence, and urgent and frequent bowel movements. In order to reduce these side effects, high-oil foods should be avoided. Roche's fresh manufacturers also recommend that users should take a low-oil, low-calorie diet. Oily stools and flatulence can be controlled by reducing fat intake to 15 grams per meal.

According to Roche, the side effects are most severe at the beginning of the conversation and will reduce the frequency of side effects over time. The XENDOS study found that only 36% of people who took this drug had gastrointestinal side effects in the fourth year, and 91% had at least one gastrointestinal side effect in the first year of the course. It has also been suggested that over time, the reduction in side effects may be associated with long-term use of a low-fat diet. On May 26, 2010, the US Food and Drug Administration (FDA) approved Xenical's revised label, including the addition of safety information that “this drug rarely causes liver damage”.

A study in Ontario reported that the rate of acute kidney injury in 900 users who received orlistat was three times greater than in the control group. The presumed mechanism of this effect is due to the intestinal absorption of excess oxalate and subsequent deposition in the kidney, while excessive oxalate absorption is a known result of fat malabsorption.

A study published in the British Medical Journal in April 2013, for the analysis of 94,695 patients taking orlistat in the UK between 1999 and 2011, found no evidence that taking orlistat would improve liver function. The risk of damage, the researchers concluded:

The incidence of acute liver injury was higher during the two periods before and after the start of the treatment with orlistat. This suggests that this observed increase in incidence may reflect a change in the patient's own health status and has no causal relationship with the use of orlistat.

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