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Raw Calcitriol Powder CAS 32222-06-3

Raw Calcitriol Powder CAS 32222-06-3

Calcitriol is a 1,25-dihydroxy metabolite in which vitamin D3 is metabolized by the liver and kidney hydroxylase to the most anti-caries activity. It can promote the absorption of calcium in the intestines; it can stimulate the original osteoclast activity or accelerate the formation of new osteoclasts, thereby promoting the absorption of bone, transferring calcium and phosphorus in the blood to human blood circulation; promoting the renal proximal tubules to calcium and The absorption of phosphorus increases the concentration of blood calcium and blood phosphorus. After oral administration, it is rapidly absorbed by the small intestine, does not require metabolic activation, and is partially degraded by the kidney.

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Raw Calcitriol Powder CAS 32222-06-3 Basic Information

Product Name: MFCD00867079; 1α,25-Dihydroxyvitamin D3;EINECS 250-963-8

CASNO.: 32222-06-3

Appearance:  white powder

Molecular Formula: C27H44O3

Molecular Weight: 416.637

Melt Point: N/A

Stocking Term: Placed in a cool dry place

Minimum Order Quantity:10 gram

Payment Term: TT/Westunion/Moneygram

Delivery Time: Shipping time usually within 24 hours after confirming payment if no accidents

Raw Calcitriol Powder CAS 32222-06-3 Indication

1. For rickets, such as vitamin D-dependent rickets, hypophosphatemia vitamin D resistant rickets.

2. Osteoporosis (mainly used in postmenopausal women and senile osteoporosis).

3. For idiopathic, pseudo, and postoperative hypoparathyroidism. Large doses of intravenous administration can be used for pseudohypoparathyroidism caused by renal failure.

4. Renal osteodystrophy caused by renal osteodystrophy, such as chronic renal failure patients (especially those undergoing hemodialysis or peritoneal dialysis).

5. For osteomalacia

Raw Calcitriol Powder CAS 32222-06-3 Adverse Reactions

1. The incidence of adverse reactions of this drug is very low, such as small doses (less than 0.5μg per day) administered alone, no adverse reactions have been observed.

2. Injection administration occasionally pain, redness and allergic reaction at the injection site.

3. Long-term high-dose medication can cause weakness, lethargy, headache, nausea, vomiting, muscle aches, bone pain, oral metal taste and so on.

Raw Calcitriol Powder CAS 32222-06-3 Medication Considerations

Young patients are limited to young idiopathic osteoporosis and osteoporosis caused by excessive glucocorticoids.

Pregnant women should not be used (animal test intake of excessive vitamin D teratogenic).

Long-term high-dose use or in combination with calcium may cause hypercalcemia and hypercalciuria.

Allergic to vitamin D and its analogues, hypercalcemia, and signs of vitamin D poisoning are contraindicated.

Raw Calcitriol Powder CAS 32222-06-3 Drug Interaction Editing

1. The use of pharmacological doses of vitamin D and its derivative preparations during the treatment of calcitriol is prohibited to avoid possible additional effects and hypercalcemia.

2. Combination with thiazole diuretics increases the risk of hypercalcemia. For patients undergoing digitalis treatment, the amount of calcitriol should be carefully established because such patients may induce arrhythmias if hypercalcemia occurs.

3. Magnesium-containing drugs may induce hypermagnesemia, so patients with long-term dialysis should avoid the use of magnesium-containing preparations when using this product.

4. The use of enzyme inducers such as diphenylacetamide or phenobarbital may increase the metabolism of calcitriol, thereby lowering its blood concentration.

5. The cholestyramine can reduce the absorption of the product by the intestine and should be avoided.

Note: The above content is only for introduction. The use of drugs must be carried out under the guidance of a doctor in a regular hospital.

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